Since most projects are one-of-a-kind creations, designing and making PCBs often doesn't make sense. PCBs are great when mass-producing a device or when the circuit complexity makes point-to-point wiring impractical. Surface-mount components with more than about three legs can be difficult -but not impossible- to use without a PCB. But, if the project is relatively simple, the PCB really isn't necessary. Most experimenters are familiar with "perf board" which is pre-drilled circuit board material. The components are mounted by inserting the leads through the most appropriate holes then are wired on the back side, usually by bending the leads over to the desired connection point. The finished product is mechanically great and the appearance is adequate. A somewhat more attractive technique employs countertop laminate which can withstand soldering temperatures without burning too badly. A drill template printed on a piece of paper is taped to the laminate on the top, attractive side. A sharp, preferably carbide, bit is used to drill the holes for the components using the template as a guide. For those of us in too much of a hurry to make a template, the holes can be marked with a fine-tipped felt pen by eye. Parts with stiff legs can be inked on a stamp pad and pressed on the laminate to leave a drilling "footprint". The picture below shows a siren circuit (found in an old GE hobby book) built on a piece of "Bermuda" blue laminate. The transistor legs were marked using the "rubber stamp" approach and the other components were marked by laying a piece of perf board on top and making little dots through the desired holes with a mechanical pencil. The holes are drilled from the top side for best results. Clamp a piece of wood to the drill press table so that the back of the laminate is supported to prevent chipping. No effort was made to make the back side attractive (no kidding!) but the back doesn't show in most cases. Two pieces of laminate could be glued together back-to-back if the appearance of both sides is an issue. The top side looks great, however! The number of available colors is overwhelming and the hobbyist can really use his imagination here. Try to acquire one of those sample chains with all of the different available colors. (The printing usually comes off with alcohol.) Clean off the soldering flux with denatured alcohol followed by detergent and water. Make sure it is dry before you apply power!
Laminate is also good for front panels. Print the mirror image of the desired markings on a piece of overhead transparency film a fix it to the laminate with a transparent spray adhesive. The laminate's texture combines with the plastic's sheen to give a really nice look. Or, just print on separate adhesive-backed labels for each control using complementary background and border colors. Coat the finished labels with a clear spray for protection. The laminate should be glued to a thin piece of hardwood plywood for stiffness.
RF projects are best built on a ground plane and often need shields between stages so an alternative to the laminate is needed. My favorite technique uses tinned, double-sided circuit board material purchased from a PCB manufacturer. It can prove surprisingly difficult to explain what you want to the manufacturer since they usually don't understand how undrilled, tinned PCB can be of any use. "But you won't be able to etch it if it is tinned" is the most common warning. Once they understand that you really don't want etching or drilling the price is usually pretty low. Get thin board (perhaps 0.031") so that it is easy to cut. Cut one piece for the ground plane and little pieces for connection "islands". I like to use an ordinary nibbling tool to make the islands. In this case, the "nibbles" are the part you want.
The islands are soldered in place by applying a little solder along one edge. The molten solder will wick underneath and the pad will be secure. There is no need to reflow the entire pad. Note the long strip of PCB material at the top of the picture used to distribute power. (Don't forget bypass capacitors!) The clock oscillator legs are bent and soldered to the little connection islands except for the ground leg which is bent a little lower so that it is flush with the ground plane. Note the surface-mount resistor soldered from the ground plane to the output island. Other surface mount parts can be accommodated in a similar manner. The tiny islands have very little capacitance to ground and the proximity of everything to the ground plane makes for a well-behaved circuit. And, since you are using double-sided board, you can have components on both sides for excellent circuit density. Drill holes wherever feedthroughs are needed. You can also use untinned copper board but soldering is more difficult and corrosion will spoil the looks.
Wood also makes an interesting substrate for many types of projects. Here is a picture of a "breadboard" three-transistor radio built in the tradition of the old Atwater-Kent breadboards:
The board is a solid plank normally used for hanging awards, medals, etc. The connections are made to ordinary solder lugs fastened to the board with wood screws. The coil is wound on a cardboard tube coated with diluted epoxy (dilute with epoxy/lacquer thinner). Various brackets, knobs and other hardware where salvaged from old equipment.